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Science

Introduction

A breakdown of each herb included in Focus Max XR, as well as the nootropic mechanisms and the relevant studies. Note that we have also included studies that find no cognitive improvements for certain extracts and dosages.

ASHWAGANDHA NOOTROPIC MECHANISMS

  • Cognition [1] [4] [5] [62]
  • Anxiety relief [2] [3] [6] [62]
  • Stress relief [2] [3] [7]
  • Fatigue relief [5]
  • Mood [5] [7]
  • Energy [5]
  • Focus [1] [4] [5]

BACOPA MONNIERI NOOTROPIC MECHANISMS

  • Cognition [8] [9] [11] [12] [13] [15] [16] [54] [55] [56] [57] [62] [63]
  • Processing Speed [8] [9] [12] [13] [15]
  • Learning [8] [13] [15] [62]
  • Memory [8] [9] [11] [13] [15] [56] [62]
  • Anxiety relief [8]
  • Fatigue relief [15]
  • Focus [8] [9] [12] [13] [15] [16] [54] [63]
  • Energy [57]
  • One study found no cognitive improvements with a certain extract and dosage. [10]

GINKGO BILOBA NOOTROPIC MECHANISMS

  • Cognition [16] [17] [18] [19] [20] [21] [22] [57] [58] [59] [60] [61] [62] [64] [65] [66]
  • Memory [16] [17] [18] [20] [21] [58] [59] [60]
  • Processing [18] [19] [21] [60]
  • Focus [18] [19] [20] [21] [60] [64] [65] [66]
  • Fatigue relief [20] [59]
  • Mood [22] [60]
  • Energy [57]
  • One study found no cognitive improvements with a certain extract and dosage. [23]

GREEN OAT STRAW NOOTROPIC MECHANISMS

  • Cognition [24] [25]
  • Stress relief [24]
  • Processing Speed [25]
  • Focus [25]

HOLY BASIL NOOTROPIC MECHANISMS

  • Cognition [26] [28] [29] [30]
  • Processing Speed [26]
  • Anxiety relief [26] [27] [28] [30]
  • Mood [27] [30]
  • Memory [26] [28] [29]
  • Neuroplasticity [28] [30]
  • Focus [26] [28] [30]
  • Stress relief [28] [29] [30]
  • Sleep [29]
  • Energy [29]

PANAX GINSENG NOOTROPIC MECHANISMS

  • Cognition [31] [32] [33] [34] [35] [36] [37] [55] [56] [57] [58] [60] [66] [67] [68]
  • Fatigue relief [31]
  • Memory [32] [35] [37] [58] [60] [67]
  • Anxiety relief [32]
  • Processing Speed [33] [36] [56] [60]
  • Mood [35] [60]
  • Focus [33] [36] [56] [60] [66] [67] [68]
  • Energy [57]

PINE BARK EXTRACT NOOTROPIC MECHANISMS

  • Cognition [38] [39] [40] [69] [70]
  • Focus [38] [39] [69] [70]
  • Memory [38] [39]
  • Mood [38] [39]
  • Anxiety relief [39]

RHODIOLA ROSEA NOOTROPIC MECHANISMS

  • Cognition [41] [42] [43] [59]
  • Processing Speed [41] [42]
  • Focus [41] [42]
  • Fatigue relief [43] [44] [45] [59]
  • Mood [43] [44]
  • Stress relief [45] [46]
  • Memory [59]

ROSEMARY NOOTROPIC MECHANISMS

  • Cognition [47] [48] [55] [57] [71]
  • Memory [47] [71]
  • Anxiety relief [47]
  • Mood [47]
  • Sleep [47]
  • Energy [57]
  • Fatigue relief [57]

SAGE NOOTROPIC MECHANISMS

  • Cognition [49] [50] [51] [52] [53] [55] [57]
  • Mood [49] [51]
  • Memory [50] [52] [53]
  • Reaction Time [53]
  • Focus [53]
  • Fatigue relief [53] [57]
  • Energy [57]

REFERENCES

[1]U. Pingali, R. Pilli, N. Fatima, Pharmacognosy Research 6 (2014) 12.

[2]M.A. Pratte, K.B. Nanavati, V. Young, C.P. Morley, The Journal of Alternative and Complementary Medicine 20 (2014) 901–908.

[3]A.L. Lopresti, S.J. Smith, Journal of Herbal Medicine 28 (2021) 100434–100434.

[4]K. Elgar, Nutr. Med. J. 1 (2021) 68–78.

[5]K. Cooley, O. Szczurko, D. Perri, E.J. Mills, B. Bernhardt, Q. Zhou, D. Seely, PLoS ONE 4 (2009) e6628.

[6]Andrade, Indian Journal of Psychiatry 42 (2021).

[7]K. Chandrasekhar, J. Kapoor, S. Anishetty, Indian Journal of Psychological Medicine 34 (2012) 255–262.

[8]Stough C, N. P, L. J, Clarke J, Hutchison C, Downey L, Rodgers T, Psychopharmacology 156 (2001) 481–484.

[9]C. Stough, L.A. Downey, J. Lloyd, B. Silber, S. Redman, C. Hutchison, K. Wesnes, P.J. Nathan, Phytotherapy Research 22 (2008) 1629–1634.

[10]P.J. Nathan, J. Clarke, J. Lloyd, C.W. Hutchison, L. Downey, C. Stough, Human Psychopharmacology Clinical and Experimental 16 (2001) 345–351.

[11]M.P. Pase, J. Kean, J. Sarris, C. Neale, A.B. Scholey, C. Stough, The Journal of Alternative and Complementary Medicine 18 (2012) 647–652.

[12]C. Kongkeaw, P. Dilokthornsakul, P. Thanarangsarit, N. Limpeanchob, C. Norman Scholfield, Journal of Ethnopharmacology 151 (2014) 528–535.

[13]J.M. Brimson, S. Brimson, M.I. Prasanth, P. Thitilertdecha, D.S. Malar, T. Tencomnao, Scientific Reports 11 (2021).

[14]L.A. Downey, J. Kean, F. Nemeh, A. Lau, A. Poll, R. Gregory, M. Murray, J. Rourke, B. Patak, M.P. Pase, A. Zangara, J. Lomas, A. Scholey, C. Stough, Phytotherapy Research 27 (2012) 1407–1413.

[15]J.D. Kean, L.A. Downey, C. Stough, Complementary Therapies in Medicine 29 (2016) 56–62.

[16]Hindmarch I, Presse Medicale (Paris, France : 1983) 15 (2019).

[17]Rigney, Phytotherapy Research : PTR 13 (2017).

[18]C. Stough, J. Clarke, J. Lloyd, P.J. Nathan, The International Journal of Neuropsychopharmacology 4 (2001).

[19]D.O. Kennedy, A.B. Scholey, K.A. Wesnes, Psychopharmacology 151 (2000) 416–423.

[20]S. Elsabagh, D. Hartley, O. Ghawil, E. Williamson, S. File, Psychopharmacology 179 (2015) 437–446.

[21]D.O. Kennedy, P.A. Jackson, C.F. Haskell, A.B. Scholey, Human Psychopharmacology: Clinical and Experimental 22 (2007) 559–566.

[22]Alarcos Cieza, P. Maier, Ernst Pöppel, Archives of Medical Research 34 (2003) 373–381.

[23]K.R. Laws, H. Sweetnam, T.K. Kondel, Human Psychopharmacology: Clinical and Experimental 27 (2012) 527–533.

[24]D.O. Kennedy, B. Bonnländer, S.C. Lang, I. Pischel, J. Forster, J. Khan, P.A. Jackson, E.L. Wightman, Nutrients 12 (2020) 1598.

[25]S. Martinez-Horta, Eran Ivanir, T. Perrinjaquet-Moccetti, M.H. Keuter, J. Kulisevsky, Frontiers in Neuroscience 15 (2021).

[26]Sampath, Indian Journal of Physiology and Pharmacology.. 59 (2015).

[27]N. Jamshidi, Rmit.edu.au (2021).

[28]N. Jamshidi, M.M. Cohen, Evidence-Based Complementary and Alternative Medicine 2017 (2017).

[29]R.C. Saxena, R. Singh, P. Kumar, Mahendra, V.S. Saxena, Periasamy Geetharani, J.J. Allan, Kudiganti Venkateshwarlu, Evidence-Based Complementary and Alternative Medicine 2012 (2011) 1–7.

[30]Bhattacharyya, Nepal Medical College Journal :, NMCJ.. 10 (2017).

[31]J.L. Reay, D.O. Kennedy, A.B. Scholey, Journal of Psychopharmacology 19 (2005) 357–365.

[32]J.L. Reay, A.B. Scholey, D.O. Kennedy, Human Psychopharmacology Clinical and Experimental 25 (2010) 462–471.

[33]S.I. Sünram-Lea, R.J. Birchall, K.A. Wesnes, O. Petrini, Current Topics in Nutraceutical Research 3 (2005) 65–74.

[34]J.L. Reay, D.O. Kennedy, A.B. Scholey, Journal of Psychopharmacology 20 (2006) 771–781.

[35]D. Kennedy, J. Reay, A. Scholey, Journal of Ginseng Research 31 (2007) 34–43.

[36]H.-B. Yeo, H.-K. Yoon, H.-J. Lee, S.-G. Kang, K.-Y. Jung, L. Kim, Journal of Ginseng Research 36 (2012) 190–197.

[37]D.O. Kennedy, A.B. Scholey, Pharmacology Biochemistry and Behavior 75 (2003) 687–700.

[38]Luzzi, Panminerva Medica 53 (2015).

[39]Belcaro G;Luzzi R;Dugall M;Ippolito E;Saggino A, Journal of Neurosurgical Sciences 58 (2019).

[40]F. Schoenlau, Elsevier EBooks (2020) 335–341.

[41]E. Jówko, J. Sadowski, B. Długołęcka, Dariusz Gierczuk, Benedykt Opaszowski, Igor Cieśliński, Journal of Sport and Health Science/Journal of Sport and Health Science 7 (2016) 473–480.

[42]T. Koop, A. Dienel, M. Heldmann, T.F. Münte, Phytotherapy Research 34 (2020) 3287–3297.

[43]A.A. Spasov, G.K. Wikman, V.B. Mandrikov, I.A. Mironova, V.V. Neumoin, Phytomedicine 7 (2000) 85–89.

[44]Fanaras Konstantinos, R. Heun, Global Psychiatry 3 (2020) 72–82.

[45]V. Darbinyan, A. Kteyan, A. Panossian, E. Gabrielian, G. Wikman, H. Wagner, Phytomedicine 7 (2000) 365–371.

[46]Emilija Ivanova Stojcheva, J.C. Quintela, Molecules 27 (2022) 3902–3902.

[47]P. Nematolahi, M. Mehrabani, S. Karami-Mohajeri, F. Dabaghzadeh, Complementary Therapies in Clinical Practice 30 (2018) 24–28.

[48]M. Moss, E. Smith, M. Milner, J. McCready, Journal of Psychopharmacology 32 (2018) 1319–1329.

[49]D.O. Kennedy, S. Pace, C. Haskell, E.J. Okello, A. Milne, A.B. Scholey, Neuropsychopharmacology 31 (2005) 845–852.

[50]K.D. Edwards, A. Dubberke, N. Meyer, S. Kugel, J. Hellhammer, (2021).

[51]A.L. Lopresti, Drugs in R&D 17 (2016) 53–64.

[52]E.L. Wightman, P.A. Jackson, B. Spittlehouse, T. Heffernan, D. Guillemet, D.O. Kennedy, Nutrients 13 (2021) 218.

[53]N. Babault, A. Noureddine, N. Amiez, D. Guillemet, C. Cometti, Frontiers in Nutrition 8 (2021).

[54]J. Sarris, J. Kean, I. Schweitzer, J. Lake, Complementary Therapies in Medicine 19 (2011) 216–227.

[55]D.O. Kennedy, Sports Sci. Exch. 29 (2019) 1–5.

[56]C. Neale, D. Camfield, J. Reay, C. Stough, A. Scholey, British Journal of Clinical Pharmacology 75 (2012) 728–737.

[57]D.O. Kennedy, Sports Medicine 49 (2019) 39–58.

[58]D.O. Kennedy, A.B. Scholey, K.A. Wesnes, Nutritional Neuroscience 4 (2001) 399–412.

[59]hayder alkuraishy, Journal of Intercultural Ethnopharmacology 5 (2015) 7–7.

[60]D.O. Kennedy, A.B. Scholey, K.A Wesnes, Physiology & Behavior 75 (2002) 739–751.

[61]D. Ong Lai Teik, X.S. Lee, C.J. Lim, C.M. Low, M. Muslima, L. Aquili, PLOS ONE 11 (2016) e0150447.

[62]C. Lorca, M. Mulet, C. Arévalo-Caro, M.Á. Sanchez, A. Perez, M. Perrino, A. Bach-Faig, A. Aguilar-Martínez, E. Vilella, X. Gallart-Palau, A. Serra, Critical Reviews in Food Science and Nutrition 63 (2022) 5521–5545.

[63]D. UP;Dingankar, Advances in Mind-Body Medicine 28 (2015).

[64]Henrik Uebel-von Sandersleben, A. Rothenberger, B. Albrecht, L.G. Rothenberger, S. Klement, N. Bock, Zeitschrift Für Kinder- Und Jugendpsychiatrie Und Psychotherapie 42 (2014) 337–347.

[65]B. Salehi, R. Imani, M.R. Mohammadi, J. Fallah, M. Mohammadi, A. Ghanizadeh, A.A. Tasviechi, A. Vossoughi, Shams-Ali Rezazadeh, Shahin Akhondzadeh, Progress in Neuro-Psychopharmacology and Biological Psychiatry 34 (2009) 76–80.

[66]Lyon, Journal of Psychiatry & Neuroscience : JPN 26 (2021).

[67]J. Lee, A. Lee, J.-H. Kim, Y.M. Shin, S.-J. Kim, W.D. Cho, S.I. Lee, Clinical Psychopharmacology and Neuroscience 18 (2020) 75–80.

[68]S.-H. Lee, W.-S. Park, M.-H. Lim, Journal of Ginseng Research 35 (2011) 226–234.

[69]C. Hsu, L. Hsieh, Y. Chen, I. Lin, Y. Chen, C. Chen, H. Shirakawa, S. Yang, Phytotherapy Research 35 (2021) 3226–3235.

[70]J. Trebatická, S. Kopasová, Z. Hradečná, K. Činovský, I. Škodáček, J. Šuba, J. Muchová, I. Žitňanová, I. Waczulíková, P. Rohdewald, Z. Ďuračková, European Child & Adolescent Psychiatry 15 (2006) 329–335.

[71]O.V. Filiptsova, L.V. Gazzavi-Rogozina, I.A. Timoshyna, O.I. Naboka, Ye.V. Dyomina, A.V. Ochkur, Egyptian Journal of Basic and Applied Sciences 4 (2017) 107–111.